OBJECTIVES
Our initial studies (Crouzier et al, Small 2009) have shown that potent osteoinductive growth factors of the BMP family (Bone Morphogenetic Proteins) can be loaded in tunable amounts in layer-by-layer films made of biopolymers. We have now taken two complementary routes: the first one consists in investigating the signaling mechanisms of BMP proteins presented in a "matrix-bound" manner by the biomaterial; the second route aims at coating BMP-loaded films onto implants that are commonly used in orthopedic, dental and maxillo-facial surgery to enhance their osteoinductive properties.
Researchers
Group Members
Vincent Fitzpatrick (PhD student)
Emeline Bourgeois (PhD student)
Ana Catarina Quintal (Master student)
Cedric Plettinx (Master student)Selected Publications
Spatio-temporal control of LbL films for biomedical applications: from 2D to 3D.Monge C, Almodóvar J, Boudou T, Picart C.
Adv. Healthc. Mater. 2015.
Spatial patterning of BMP-2 and BMP-7 on biopolymer films and the guidance of muscle cell fate. Almodovar J, Guillot R, Monge C, Vollaire J, Seilimovic S, Coll JL,
Khademhosseini A, Picart C.
Biomaterials. 2014.
The stability of BMP loaded polyelectrolyte multilayer coatings on titanium.Guillot R, Gilde F, Becquart P, Sailhan F, Lapeyrere A, Logeart-Avramoglou D,
Picart C.
Biomaterials. 2013.
Secondary structure of rhBMP-2 in a protective biopolymeric carrier material.Gilde F, Maniti O, Guillot R, Mano JF, Logeart-Avramoglou D, Sailhan F, Picart C.
Biomacromolecules. 2012.
The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating.Crouzier T, Sailhan F, Becquart P, Guillot R, Logeart-Avramoglou D, Picart C.
Biomaterials. 2011.
Presentation of BMP-2 from a soft biopolymeric film unveils its activity on cell adhesion and migration.Crouzier T, Fourel L, Boudou T, Albiges-Rizo C, Picart C.
Adv. Mat. 2011.
Layer-by-layer films as a biomimetic reservoir for rhBMP2 delivery : controlled differentiation of myoblasts to osteoblasts.Crouzier T, Ren K, Nicolas C, Roy C, Picart C.
Small. 2009.