SEMINAIRE LMGP - 28.03.2023 - Pr. Camelia BALA

“Surface modification for chemical and biochemical sensing”


Pr. Camelia BALA
University of Bucharest, Department of Analytical and Physical Chemistry, Bucharest, Romania

Abstract

This lecture intends to be an overview on the research activity developed by our group in the sensing field, especially the design of the interface between the physical transducer and the biological recognition elements. The immobilization of the active biological component on the transducer surface represents a critical stage in the biosensors development and it has as a goal the settlement of the bioactive part on the surface of the physical transducer. The chosen immobilization procedure has to keep the biological component in the native conformation. On the other hand, the physical transducers should have an adequate sensitivity toward the species to be detected.

The lecture will illustrate the practical applications of physical, organic, and inorganic chemistry for surface modification of electrochemical and SAW sensors, focusing on layer-by-layer assembly and thiol-driven self-assembly and sol-gel chemistry, grafting chemistries including click chemistry and practical applications from environmental and biomedical analysis areas.