OBJECTIVES
Our goal is to control the binding of active molecules on 2D platforms for studying cellular responses in vitro. Thanks to the use of surface sensitive techniques the functionalization of our platforms is quantitatively controlled and studies on molecular interactions are allowed. The 2D platforms are, moreover, used as substrate for cellular studies such as differentiation, migration and signaling activation. We are in particular looking at the effect of a glicosamminoglycan named heparan sulfate on bone morphogenetic protein 2 activity on murine and human stem cells.
Researchers
Group Members
Julius Sefkow-Werner (PhD student)
Jean Le Pennec (M2 student)
Elaine Castro (M1 student)
Adrià Sales (postdoc)
Jean Le Pennec (M2 student)
Elaine Castro (M1 student)
Adrià Sales (postdoc)
Previous group Members
Simon Peyras (M1 student)
Paper accepted in Biointerphases: Migliorini E et al. Dec 2018
Practical guide to characterize biomolecule adsorption on solid surfaces (Review)
IDEX-IRS funding 2018–2021
PhD position for Julius Sefkow-Werner starting in October 2018
Welcome Julius
Julius Sefkow-Werner PhD student 
Elisa Migliorini*, Patrick Horn, Tamás Haraszti, Seraphine V. Wegner, Christian Hiepen,
Petra Knaus, Ralf P. Richter and E. Ada Cavalcanti-Adam*
Adv. Biosys. 2017, 1600041.
DOI: 10.1002/adbi.201600041
Thakar Dhruv, Dalonneau Fabien, Migliorini Elisa, Lortat-Jacob Hugues, Boturyn Didier, Coche-Guerente Liliane, Picart Catherine and Richter Ralf P. Biomaterials. 2017;123:24-38. doi.org/10.1016/j.biomaterials.2017.01.022
Tuning cellular responses to BMP-2 with material surfaces. Migliorini Elisa, Valat Anne, Picart Catherine, Cavalcanti-Adam Elisabetta Ada. CGFR. 2016;27:43-54. doi: 10.1016/j.cytogfr.2015.11.008