OBJECTIVES
We are combining 3D scaffold and 2D bioactive coating to create biomimetic cancer niches. The bioactive coatings are made using the layer-by-layer assembly. They can deliver bioactive molecules, including chemokines, hydrophobic drugs and peptides. We aim to understand how breast cancer cells respond to specific stimuli and to optimize drug treatments in cancers.
Funding: Fond Unique Interministeriel (FUI) 3D ONCOCHIP (PI CTI Biotech), Fondation ARC pour la Recherche Contre le Cancer
Funding: Fond Unique Interministeriel (FUI) 3D ONCOCHIP (PI CTI Biotech), Fondation ARC pour la Recherche Contre le Cancer
Researchers and Technical Staff
Catherine Picart (CEA, Research Director)
Paul Machillot (CNRS, Assistant Engineer)
Lauriane Bosc (Engineer, CDD)
Paul Machillot (CNRS, Assistant Engineer)
Lauriane Bosc (Engineer, CDD)
Students
Selected Publications
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Biomaterials-enabled delivery of SDF-1a at the ventral side of breast cancer cells reveals a crosstalk between cell receptors and to promote the invasive phenotype.
Biomaterials-enabled delivery of SDF-1a at the ventral side of breast cancer cells reveals a crosstalk between cell receptors and to promote the invasive phenotype.
Liu XQ, Fourel, L., Dalonneau, F., Sadir, R., Leal, S., Lortat-Jacob, H., Weidenhaupt, M., Albiges-Rizo, C., Picart C.
Biomaterials. 2017.
The effect of delivering the chemokine SDF-1alphe in a matrix-bound manner on myogenesis.Dalonneau F, Liu XQ, Rabir R, Almodovar J, Mertani HC, Bruckert C, Mertani H, Albiges-Rizo C, Weidenhaupt M, Lortat-Jacob H, Picart C.
Biomaterials. 2014.
Asymmetric free-standing film with multifunctional anti-bacterial and self-cleaning properties.Shen L, Wang B, Wang J, Fu J, Picart C, Ji J.
ACS Appl. Mater. Interfaces. 2012.
Polyelectrolyte multilayer nanoshells with hydrophobic nanodomains for the delivery of Paclitaxel.Boudou T, Kharkar P, Jing J, Guillot R, Pignot-Paintrand I, Auzely-Velty R, Picart C.
J. Control. Release. 2012.
Hydrophobic shell loading of biopolyelectrolyte capsules.
Cui D, Jing J, Boudou T, Pignot-Paintraind I, De Koker S, De Geest BG, Picart C, Auzély-Velty R.
Adv. Mater. 2011.
Adv. Mater. 2011.
Contact-killing polyelectrolyte microcapsules based on chitosan derivatives.
Cui D, Anna Szarpak A, Pignot-Paintrand I, Varrot A, Boudou T, Detrembleur C,
Jérôme C, Picart C, Auzély-Velty R.
Adv. Funct. Mat. 2010.
Jérôme C, Picart C, Auzély-Velty R.
Adv. Funct. Mat. 2010.