LMGP_IMBM_Insuline at triple interface 2022

Biomaterials for cancer therapy


We are combining 3D scaffold and 2D bioactive coating to create biomimetic cancer niches.  The bioactive coatings are made using the layer-by-layer assembly. They can deliver  bioactive molecules, including chemokines, hydrophobic drugs and peptides. We aim to understand how breast cancer cells respond to specific stimuli and to optimize drug treatments in cancers.
Funding: Fond Unique Interministeriel (FUI) 3D ONCOCHIP (PI CTI Biotech), Fondation ARC pour la Recherche Contre le Cancer

Researchers and Technical Staff

Catherine Picart (CEA, Research Director)
Paul Machillot (CNRS, Assistant Engineer)
​​​​​​​Lauriane Bosc (Engineer, CDD)


Arunkumar Rengaraj (Post-doc Association Recherche Contre le Cancer)


Selected Publications

style4;] Biomaterials-enabled delivery of SDF-1a at the ventral side of breast cancer cells reveals a crosstalk between cell receptors and to promote the invasive phenotype.
Liu XQ, Fourel, L., Dalonneau, F., Sadir, R., Leal, S., Lortat-Jacob, H., Weidenhaupt, M., Albiges-Rizo, C., Picart C.
Biomaterials. 2017.

The effect of delivering the chemokine SDF-1alphe in a matrix-bound manner on myogenesis.
Dalonneau F, Liu XQ, Rabir R, Almodovar J, Mertani HC, Bruckert C, Mertani H, Albiges-Rizo C, Weidenhaupt M, Lortat-Jacob H, Picart C.
Biomaterials. 2014.
Asymmetric free-standing film with multifunctional anti-bacterial and self-cleaning properties.
Shen L, Wang B, Wang J, Fu J, Picart C, Ji J.
ACS Appl. Mater. Interfaces. 2012.
Polyelectrolyte multilayer nanoshells with hydrophobic nanodomains for the delivery of Paclitaxel.
Boudou T, Kharkar P, Jing J, Guillot R, Pignot-Paintrand I, Auzely-Velty R, Picart C.
J. Control. Release. 2012.
Hydrophobic shell loading of biopolyelectrolyte capsules.
Cui D, Jing J, Boudou T, Pignot-Paintraind I, De Koker S, De Geest BG, Picart C, Auzély-Velty R.
Adv. Mater. 2011. 
Contact-killing polyelectrolyte microcapsules based on chitosan derivatives.
Cui D, Anna Szarpak A, Pignot-Paintrand I, Varrot A, Boudou T, Detrembleur C,
Jérôme C, Picart C, Auzély-Velty R.
Adv. Funct. Mat. 2010.