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Synthèse et propriétés de monocristaux, de poudres, films minces ou hétérostructures

Etudes à l'interface avec la matière biologique

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Publication par Franz Bruckert 2017

Publié le 30 novembre 2017
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Communiqué du 7 décembre 2017 au 21 décembre 2017

Le papier "Diamagnetically trapped arrays of living cells above micromagnets" a été publié dans Lab on a Chip

Ici  vous trouverez le papier de Franz Bruckert

"Cell arrays are of foremost importance for many applications in pharmaceutical research or fundamental biology. Although arraying techniques have been widely investigated for adherent cells, organization of cells in suspension has been rarely considered. The arraying of non-adherent cells using the diamagnetic repulsive force is presented. A planar arrangement of Jurkat cells is achieved at the microscale above high quality microfabricated permanent magnets with remanent magnetization of Jr ≈ 1 T, in the presence of a paramagnetic contrast agent. The cytotoxicity of three Gd based contrast agents, Gd-DOTA, Gd-BOPTA and Gd-HP-DO3A, is studied. Among them, Gd-HP-DO3A appears to be the most biocompatible toward Jurkat cells. In close agreement with analytical simulations, diamagnetically ‘suspended’ cells have been successfully arrayed above square and honeycomb-like micromagnet arrays, which act as a “diamagnetophobic” surface. Living cell trapping is achieved in a simple manner using concentrations of Gd-HP-DO3A as low as 1.5 mM."

 



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mise à jour le 30 novembre 2017

  • Tutelle CNRS
  • Tutelle Grenoble INP
Université Grenoble Alpes