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SEMINAR LMGP - 16.06.2020 - Monica VALLEJO PEREZ

Published on May 29, 2020
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Seminar June 16, 2020
at 2 p.m. - by visioconference

Development of biosensors based on randomly oriented Si nanowires for electrical detection of DNA hybridization

Monica VALLEJO PEREZ

Monica VALLEJO PEREZ

Monica VALLEJO PEREZ
PhD student / LMGP - Department of Molecular Chemistry (DCM)

Abstract
A biosensor has the function of detecting and in some cases also quantifying a specific analyte, through the interaction between a biological element, called probe molecule, capable of generating a recognition event at the moment of interacting with its target, and a physical element that acts as a transducer, converting the recognition event into a detectable signal.
Our aim is to develop a biosensor capable of electrically detecting DNA hybridization, through a device fabricated from a new material: networks of randomly oriented Si nanowires (Si nanonets).
For this purpose we have worked on three different steps: (i) Fabrication of a Si nanonet Field Effect Transistor (FET), (ii) Biofunctionalization of Si nanonet FETs for covalent grafting of the probe molecules on the devices, and (iii) Electrical detection of the target molecule.
The development, challenges and results obtained for each of the previously mentioned steps will be thoroughly detailed.
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Date of update May 29, 2020

Université Grenoble Alpes