Fadel A. Samatey Associate Professor Trans-Membrane Trafficking Unit Okinawa Institute of Science and Technology - Okinawa - Japan
The bacterial Flagellum: are old stories still true?
Abstract The bacterial flagellum, a complex and well-designed nano-machine has been extensively studied, mainly in the case of E. coli and Salmonella typhimurium (S. typhimurium). It has been shown that the axial proteins of the flagellum are organized in a helical tubular structure that can be described as an assembly of 11 protofilaments. It has long been accepted that this assembly into 11 protofilaments was valid for all flagellated bacteria. However, recent studies have shown that the flagellar filament of Campylobacter jejuni (C. jejuni) is composed of seven protofilaments instead of eleven protofilaments as found in other flagellated bacteria. How really different is the quaternary structure of the flagellum from Campylobacter jejuni? Could all the axial proteins of C. jejuni flagellum also have a structure made of 7 protofilaments? During the presentation, I will talk about our recent results and discuss on the difference between C. jejuni and S. typhimurium flagellum.