Access : TRAM B - Stop at "Cité internationale" Free entrance - No registration
Dr. Johnna S. Temenoff Associate Professor Coulter Department of Biomedical Engineering Georgia Institute of Technology/Emory University, Atlanta (USA)
Glycosaminoglycan-based Biomaterials for Mesenchymal Stem Cell Differentiation
Multipotent mesenchymal stem cells (MSCs) have been widely explored as a means to repair or regenerate a variety of tissues, particularly in orthopaedics. However, how these cells respond to cues from their environment, particularly soluble signals, to determine cell fate remains largely unknown. We have recently developed a family of glycosaminoglycan (GAG)-based biomaterials to modulate cellular response to soluble cues. Our results suggest that material sulfation level plays a role in mesenchymal stem cell differentiation into orthopaedic-related phenoytpes, and that this may be exploited in controlled ways to direct differentiation of stem cells both before and after implantation to achieve maximal healing of orthopaedic defects.
Dr. Johnna Temenoff completed her Ph.D. in 2003 from Rice University, after graduating from Case Western Reserve University in 1998 with a B.S. in Biomedical Engineering and a B.A. in French. Johnna remained at Rice 2003-2005 to co-author an undergraduate biomaterials textbook with Dr. Mikos. The result, Biomaterials: The Intersection of Biology and Materials Science, published in 2008 by Pearson-Prentice Hall, has been adopted by over 50 universities in the U.S. and has been published in two international editions. This book also won the Meriam-Wiley award in 2010 for best new engineering textbook from the American Society of Engineering Education. In 2005, Johnna joined the faculty of the Coulter Department of Biomedical Engineering at Georgia Tech/Emory University in Atlanta, GA. Her research in the area of novel GAG-based polymeric materials for regeneration of orthopaedic tissues has earned her an Arthritis Foundation Investigator Award in 2006 and a U.S. NSF CAREER Award in 2008, as well as funding from several U.S. NIH grants.